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KMID : 0370019890030000055
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Chung-Ang Journal of Pharmacal Sciences
1989 Volume.3 No. 0 p.55 ~ p.64
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Effects of Dopaminergic Agonists and Antagonists on Bethanechol-Stimulated Gastrointestainal Motility in the 6-Hydroxydopamine-Pretreated Mice
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Abstract
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This experiment was set up to investigate the effect of dopaminergic agonists and antago-nists on bethanechol-stimulated gastrointestinal motility, and also effect of these drugs after 6-OHDA pretreated in neonatal and adult mice, effect of metoclopramide, besides, according to a dose on bethanechol stimulated gastrointed gastrointestinal motility in mice.
The results obtained are as follows :
1. On the normal control group, bromocriptine (10 mg/kg, i.p.), apomorphine (2 mg/kg, i.p.), lisuride(100㎍/kg,i.p.), which are dopaminergic agonists, significantly inhibited bethane-chol-stimulated gastrointestinal motility. Metoclopramide (10 mg/kg, i.p.), clebopride (5 mg/kg, i.p.), which are dopaminergic antagonists, did not affect. On the other hand, sulpi-ride(40 mg/kg, i.p.), exhibited inhibitory effect on the gastrointestinal motility.
2. On the neonatal mice group pretreated with 6-OHDA, apomorphine exhibited significantly inhibitory effect, but bromocriptine and lisuride did not affect. Sulpiride exhibited signifi-cantly inhibitory effect.
3. On the adult mice group pretreated with 6-OHDA, bromocriptine, apomorphine, lisuride ex-hibited inhibitory effect. Metoclopramide potentiated the bethanechol-stimulated gastroin-testinal motility, on the hand, sulpiride inhibited.
4. Metoclopramide 2.5,5,10 mg/kg showed increase, but not significant, metoclopramide 80 mg/kg showed significant inhibition.
5. After 6-OHDA pretreated in adult mice, metoclopramide 10 mg/kg potentiated gastrointes-tinal motility, but metoclopramide 80 mg/kg exhibited significant inhibition.
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